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KMID : 0366220170520020106
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Korean Journal of Hematology
2017 Volume.52 No. 2 p.106 ~ p.111
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Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
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Akbarin Mohammad Mehdi
Shirdel Abbas
Bari Alireza
Mohaddes Seyedeh Tahereh
Rafatpanah Houshang
Karimani Ehsan Ghayour
Etminani Kobra
Golabpour Amin
Torshizi Reza
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Abstract
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Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive malignancy with very poor prognosis and short survival, caused by the human T-lymphotropic virus type-1 (HTLV-1). The HTLV-1 biomarkers trans-activator x (TAX) and HTLV-1 basic leucine zipper factor (HBZ) are main oncogenes and life-threatening elements. This study aimed to assess the role of the TAX and HBZ genes and HTLV-1 proviral load (PVL) in the survival of patients with ATLL.
Methods: Forty-three HTLV-1-infected individuals, including 18 asymptomatic carriers (AC) and 25 ATLL patients (ATLL), were evaluated between 2011 and 2015. The mRNA expression of TAX and HBZ and the HTLV-1 PVL were measured by quantitative PCR.
Results: Significant differences in the mean expression levels of TAX and HBZ were observed between the two study groups (ATLL and AC, P =0.014 and P=0.000, respectively). In addition, the ATLL group showed a significantly higher PVL than AC (P=0.000). There was a significant negative relationship between PVL and survival among all study groups (P =0.047).
Conclusion: The HTLV-1 PVL and expression of TAX and HBZ were higher in the ATLL group than in the AC group. Moreover, a higher PVL was associated with shorter survival time among all ATLL subjects. Therefore, measurement of PVL, TAX, and HBZ may be beneficial for monitoring and predicting HTLV-1-infection outcomes, and PVL may be useful for prognosis assessment of ATLL patients. This research demonstrates the possible correlation between these virological markers and survival in ATLL patients.
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KEYWORD
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HTLV-1, ATLL, TAX, HBZ, Proviral load
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